Axonal regeneration through acellular muscle grafts
نویسندگان
چکیده
منابع مشابه
Axonal regeneration through acellular muscle grafts.
The management of peripheral nerve injury remains a major clinical problem. Progress in this field will almost certainly depend upon manipulating the pathophysiological processes which are triggered by traumatic injuries. One of the most important determinants of functional outcome after the reconstruction of a transected peripheral nerve is the length of the gap between proximal and distal ner...
متن کاملAxonal regeneration into acellular nerve grafts is enhanced by degradation of chondroitin sulfate proteoglycan.
Although the peripheral nerve has the potential to regenerate after injury, degenerative processes may be essential to promote axonal growth into the denervated nerve. One hypothesis is that the nerve contains growth inhibitors that must be neutralized after injury for optimal regeneration. In the present study, we tested whether degradation of chondroitin sulfate proteoglycan, a known inhibito...
متن کاملMetalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts.
Injury to peripheral nerve initiates a degenerative process that converts the denervated nerve from a suppressive environment to one that promotes axonal regeneration. We investigated the role of matrix metalloproteinases (MMPs) in this degenerative process and whether effective predegenerated nerve grafts could be produced in vitro. Rat peripheral nerve explants were cultured for 1-7 d in vari...
متن کاملIntrastriatal grafts of rat colonic smooth muscle lacking myenteric ganglia stimulate axonal sprouting and regeneration.
Grafts of living or freeze-killed freshly dissected colonic smooth muscle from young inbred Fischer rats were implanted into the corpus striatum of adult Fischer rats. Sections of brain were examined electron microscopically 3 and 6 wk after implantation. At both times, living grafts were vascularised and contained healthy differentiated smooth muscle cells, fibroblasts, interstitial cells of C...
متن کاملRegeneration of facial nerve defects with xenogeneic acellular nerve grafts in a rat model.
BACKGROUND Because of ease of harvest and low immunogenicity, xenogeneic acellular nerve graft (XANG) may be an alternative to autologous nerve to repair facial nerve defects. METHODS Facial nerve defects of Wistar rats were repaired by XANG, and nerve gap regeneration was investigated by electrophysiological test, horseradish peroxidase (HRP) retrograde tracing and histomorphometric analysis...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 1997
ISSN: 0021-8782,1469-7580
DOI: 10.1046/j.1469-7580.1997.19010057.x